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Technology
Access for our Customers
Graffinity offers numerous benefits
to its customers on a straightforward
basis with no downstream obligations.
In
the first step the customer provides target protein to
Graffinity. Graffinity then performs SPR imaging based
fragment screening with the drug target. Subsequently, the resulting
data are used for a comprehensive SAR analysis which will be
delivered three-months after receipt of the target protein by
Graffinity. As the key result of a project Graffinity finally
delivers an agreed upon number of hit compounds to the customer for
secondary assays.
Graffinity´s process delivers
• Window to novel, diverse chemistry
• Fragments and low affinity binders build the basis for
novelty
• Novel binding modes can be characterized early
• Fastest read on druggability of targets
• Earliest look at SAR that is technically possible
• Technology and process scalable to any number of targets
Partnering contact:
Dr. Thomas Neumann
Im Neuenheimer Feld 518
69120 Heidelberg, Germany
Phone: +49(0)6221 6510 0
Fax: +49(0)6221 6510 111
E-Mail: thomas.neumann [at] graffinity.com
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• Various metabolic enzymes
• Kinases
(full
length, catalytic domains)
• Proteases
• Protein-protein interaction targets
• Esterases
• Nuclear hormone receptors
• Total more than 85 targets successfully tested since
2003. |
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