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Products
Graffinity offers numerous benefits to its customers on a straighforward,
fee-for-service technology access program.
The client provides target material, Graffinity will perform
the fingerprint program and active compounds are designed based
on fingerprint analysis. Graffinity delivers an agreed upon
number of compounds to its clients for secondary assays.
This technology can be accessed via two products. |
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access program products |
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HitRAISE
4-6 month program, usually multitarget, deliverable is set of
compounds with activity against the target
LeadRAISE
4-6 month HitRAISE program (see above) plus additional 6 month
chemistry program
deliverable is compounds with activities below 1 µM, secure
IP position, In vitro selectivity profile, and cell activity.
Other parameters can be adjusted to customers need.
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Protein
requirements
 Soluble
protein with 80% purity
4
mg for 110,000 data points (40 kDa protein)
Buffer
conditions can be widely adapted
Possible array screening
experiments
Affinity
fingerprinting
Binding
site mapping on target by on-array competition with known
inhibitor
Current array content
Graffinity
collection of 110,000 cmpds on 16 different arrays
Customer
content possible but not general practice |
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